Scientists successfully developed bioactive spider silk structure
With the development of science and technology, at present, researchers can use the new technology to synthesize a filamentous material with similar mechanical properties as a genuine spider silk, which may be expected to be applied to treat various types of diseases such as cancer. In recent days, In a research report in the international journal Advanced Materials, a researcher from Stockholm developed a new method to create a bioactive spider silk structure.
Due to their good strength and elasticity, scientists have attracted the attention of scientists for their potential applications. Researchers hope to use spider silk as a scaffold for tissue repair, drug delivery, biomarker sensing or antibacterial coating Layer and so on. But finding a satisfactory way to synthesize proteins that simulate spider silk appears to be very elusive for scientists. Researchers Hedhammar said that we are trying to start the simulation spinning process using microfluidics, wet spinning and electrospinning techniques, many of which are very difficult to design and require harsh chemicals such as methanol to make the yarn in After the formation of insoluble in water, to avoid the loss of its biological activity.
Based on this, the researchers utilized a new, recently developed biochemical technique that uses microimage surfaces to concentrate proteins to form organic nanowires or coatings. Like a very small brush, the researchers used a micro-silica column on the surface that was somewhat hydrophobic; then the researchers devised two types of filamentous proteins, one of which had a high degree of resistance to the antibody Affinity, while the other has cell-binding properties.
By removing soluble filamentous protein droplets from the top of the miniature silicon column, the researchers completed three different forms of synthetic filamentary structures, namely nanowires (which can be used as cancer therapeutics), local coatings For the detection of biomarkers) and silk sheets that can be used as a cell growth scaffold. For example, in order to develop nanowires, researchers placed droplets on this very tiny image surface structure, then dragged the droplet, leaving a lot of thread material on the pillar.
Similarly, in order to develop a silky structure, researchers placed droplets on top of the microtitre image surface and the resulting silky structure was tested for stability by immersion in water and cell culture media; the researchers concluded that this The new silk structure has a certain integrity, it does not show any signs of dissolution, which confirmed that the special protein can be successfully transformed into a stable filamentous structure. (Bio Valley Bioon.com)